Dengue 1 virus and dengue hemorrhagic fever, french. Management of severe dengue hemorrhagic fever and bleeding. Symptoms typically begin three to fourteen days after infection. In this study most of our patients 89% presented in the post monsoon periods august november. Dengue fever, also known as breakbone fever, is a mosquitoborne infectious tropical disease caused by the dengue virus. In india the annual incidence is estimated to be 7. The first dengue fever in india was reported during 1956 from vellore and the first dengue haemorrhagic fever occurred in calcutta in 1963. Pdf clinical profile and outcome in children of dengue. Gallbladder wall thickening in dengue hemorrhagic fever. Infection may be asymptomatic or present with a broad range of clinical manifestations including a mild febrile illness to a lifethreatening shock syndrome. Description of the clinical picture of dengue hemorrhagic feverdengue shock syndrome dhfdss in adults. Hasitha tissera, abhay p s rathore, wei yee leong, brian l pike, tyler e warkentien, farouk s farouk, ayesa syenina, eng eong ooi, duane j gubler, annelies wildersmith, ashley l st.
In 2010 guidelines were developed on the management of dengue fever and dengue haemorrhagic fever in children and adolescents. This is probably due to the fact that these signs have been included in the definition of dengue hemorrhagic fever since 1997. Dengue hemorrhagic fever dhf is a specific syndrome that tends to affect children under 10 years of age. Dhf starts abruptly with high continuous fever and headache plus respiratory and intestinal symptoms with sore throat, cough, nausea, vomiting, and abdominal pain. Dengue fever symptoms, causes, contagious, rash, prevention. Try to estimate the, clinical practice guidelines of denguedengue hemorrhagic fever management for asian economic community. Dengue is a febrile illness caused by a flavivirus transmitted by aedes aegypti or aedes albopictus mosquitoes while taking a blood meal. The effect of overnutrition toward the risk of dengue shock syndrome. Chymase level is a predictive biomarker of dengue hemorrhagic. Dengue and dengue hemorrhagic fever dengue shock syndrome. Symptoms deteriorated after admission, and the patient was subsequently diagnosed with dhf. A pediatric case of imported dengue hemorrhagic fever in. Dengue fever causes high fever, rash, and muscle and joint pain, bleeding, and hypotension.
Dengue, dengue haemorrhagic fever and dengue shock. It is a mosquitoborn disease caused by genus aedes. Dengue viral infections postgraduate medical journal. The first recorded epidemic of dengue was reported in the late 18thcentury and affected asia, africa, and north america. American journal of tropical medicine and hygiene, 1969, 18. Surveillance data from hospitalized casepatients showed that casepatients with dengue hemorrhagic fever dhf exhibited a bimodal age distribution with 1 peak among infants 610 months of age and a second peak at 411 years of age. Mediterranean journal of hematology and infectious diseases, 101, e2018021. Dengue fever list of high impact articles ppts journals. We aimed to analyze the variation in clinical spectrum, outcome and possible risk factors. Dec 07, 2018 some patients with dengue fever go on to develop dengue hemorrhagic fever, a severe and sometimes fatal form of the disease. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever vii dengue fever is the fastest emerging arboviral infection spread by aedes mosquitoes with major public health consequences in over 100 tropical and subtropical countries in southeast asia, the western pacific and south and central america.
Researchers estimate 390 million infections yearly, of. However, the atypical clinical presentation in dengue can also be seen. Dengue fever is an acute febrile disease caused by infection with one of the serotypes of dengue virus. A pediatric case of imported dengue hemorrhagic fever in japan. A study on clinical presentation of dengue fever in children. Predicting the severity of dengue fever in children on admission. Denv is transmitted principally by aedes aegypti and aedes albopictus mosquitoes and causes dengue fever and the more severe dengue hemorrhagic fever dengue shock syndrome dhfdss throughout tropical and subtropical regions. Siddappa fd 1, koushik h 2, v h ratageri 1, p k wari 1. It causes approximately 390 million cases per year and puts an estimated 3. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash.
In india, dengue epidemics are becoming more frequent who, 2008. Dengue fever quick facts adapted from the cdc what is dengue. Abstract we report a case of imported dengue hemorrhagic fever dhf in a 10. Dengue fever and dengue hemorrhagic fever morens, david m. Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. In odisha, a state of eastern india, the first outbreak was reported in 2010, followed by extensive outbreaks in 2011, affecting a. Dengue fever is caused by dengue virus of genus falvivirus.
Dengue dengue hemorrhagic fever management for asian economic community. Patients with suspected dengue infection were classified further into 2 groups, dengue fever probable dengue, dengue with warning signs and severe dengue dengue hemorrhagic fever andor dengue shock syndrome dhfdss according to who. Dengue fever, dengue hemorrhagic fever, dengue shock syndrome. Dengue hemorrhagic fever nursing care management and study guide. Annually, 100 million cases of dengue fever and half a million cases of dhf occur worldwide. Df is an acute febrile illness that presents symptoms such as bone or joint and muscular pains, headaches, leukopenia and rash. It presents with acute onset of fever with nonspecific constitutional symptoms and signs of hemorrhagic diathesis, which may progress to fatal shock dengue shock syndrome, dss.
An epidemic of dengue 1 virus denv1 occurred in french polynesia in 2001, 4 years after a denv2 epidemic that ended in 1997. Clinical practice guidelines of denguedengue hemorrhagic. Dengue is a febrile illness caused by infection with one of four dengue viruses denv transmitted by aedes aegypti or aedes albopictus mosquitoes during the taking of a blood meal. Df was first recognized during a dengue epidemic in the philippines in 1950, and. Dengue fever and dengue hemorrhagic fever in adolescents and adults. Dengue fever, a very old disease, has reemerged in the past 20 years with an expanded geographic distribution of both the viruses and the mosquito vectors, increased epidemic activity, the development of hyperendemicity the cocirculation of multiple serotypes, and the emergence of dengue hemorrhagic fever in new geographic regions. Trends in patterns of dengue transmission over 4 years in a. A total of 77 cases were classified into 67 87% nonsevere and 10 % severe dengue cases. There are four dengue virus denv types denv1, denv2, denv3, and denv4, all of which are capable of inducing severe disease dengue hemorrhagic fever dhfdengue shock syndrome dss. Natural history of plasma leakage in dengue hemorrhagic fever. Although plasma leakage is the major cause of mortality and morbidity in patients with dengue hemorrhagic fever dhf, a detailed assessment of the natural course of this process is still lacking. Dengue fever is a reemerging viral disease commonly occurring in tropical. Get new journal tables of contents sent right to your email inbox get new issue alerts.
Dss in dengue pediatric patient by evaluating the adiponectin. Use of warning signs for dengue by pediatric health care. John, chymase level is a predictive biomarker of dengue hemorrhagic fever in pediatric and adult patients, the journal of infectious diseases, volume 216, issue 9. The aim of this study was to describe the use of dengue warning signs by pediatric healthcare staff in the brazilian public health care system. Since the second edition of dengue haemorrhagic fever. This acute febrile illness can be a deadly infection in cases of severe manifestation, causing dengue hemorrhagic shock.
Currently, there are no dengue specific treatments or vaccines available, although one. Clinical features vary with the age of the patient although clinically occult infection occurs in about 80% 9. Symptoms include fever, headache, muscle and joint pains, and a. However, a clinician must be particularly watchful in treating a pregnant dengue infected patient as physiologic hematology changes provide greater volume compensation and the advent of.
A90 dengue fever a91 dengue hemorrhagic fever a91 a dengue shock syndrome a99 unconfirmed dengue clinical presentation of dengue infections dengue viruses which have 4 serotypes. Other members of the same genus include yellow fever virus, west nile virus, zika virus, st. To date, there is no known cure for dengue fever df, the worlds fastest spreading mosquitoborne viral disease transmitted mainly by female aedes aegypti mosquitoes. The perception of low platelet count as a sign of severity in dengue is consistent with a study on primary care physicians knowledge in singapore, where 52% reported using platelet count below 80,000 as a criterion. We report a case of imported dengue hemorrhagic fever dhf in a 10. Louis encephalitis virus, japanese encephalitis virus, tickborne encephalitis virus, kyasanur forest disease virus, and omsk hemorrhagic fever virus. The association between obesity and dengue severity. Dengue fever df is caused by infection with 1 of 4 dengue virus denv serotypes 1. For typical dengue fever, the treatment is directed toward relief of the symptoms symptomatic treatment. Dengue hemorrhagic fever dhf is a severe form of dengue fever df, which can be life threatening.
Children less than 15 years are the most common victims. In the early 1950s, the disease was described in the philippines as hemorrhagic fever or infectious acute thrombocytopenic purpura 1, 2. Overnutrition, pediatric, dengue hemorrhagic fever, adiponectin, svcam1. This has clearly helped reduce the mortality due to dengue. Dengue hemorrhagic fever can occur when someone is bitten by a mosquito or exposed to blood infected with the dengue virus. Trends in patterns of dengue transmission over 4 years in. Ninety percent of dhf subjects are children less than 15 years of age. Clinically, the manifestations of denv infection can range from mildacute undifferentiated febrile illness to classical dengue fever df, dengue hemorrhagic fever dhf, and dengue shock syndrome dss according to who 1997 dengue guideline 1. Dec 20, 2016 fever, thrombocytopenia, and hemoconcentration are the classical symptoms of dengue hemorrhagic fever observed in adult, pediatric, and obstetric populations. Bali medical journal bali med j 2018, volume 7, number 1. In a small proportion of cases, the disease develops into severe dengue, also known as dengue. Dengue virus infection is often inapparent,11, 15 but can lead to a wide range of clinical manifestations, from mild fever to plasma leakage and the potentially fatal dengue shock syndrome. A syndrome due to the dengue virus that tends to affect children under 10, causing abdominal pain, hemorrhage bleeding and circulatory collapse. Dengue fever is mostly occurs in children and young adults 8.
Dengue haemorrhagic fever typical cases of dhf are characterized by four major clinical manifestations. Clinical profile and outcome of dengue fever and dengue haemorrhagic fever in pediatric age group. Dengue is a selflimiting acute mosquito born disease caused by dengue virus. Cardiac manifestations of dengue fever in children. Can hematocrit and platelet determination on admission predict shock in hospitalized children with dengue hemorrhagic fever. Denguedengue hemorrhagic fever management for asian economic community. The new icd10, dengue infections are classified as follow. Clinical and serologic study of cuban children with dengue hemorrhagic feverdengue shock syndrome dhfdss. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female aedes mosquitoes. Patients with obesity were found to be at higher risks of developing complications and severe dengue infection compared to nonobese patients. It is an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pain, swollen lymph nodes lymphadenopathy, and rash. Knowledge, attitude, and practices regarding dengue fever. The majority of dengue viral infections are selflimiting, but complications may cause high morbidity and mortality.
Asia, where in many countries dengue is a leading cause of paediatric hospitalisation. Clinical practice guidelines of denguedengue hemorrhagic fever management for asian economic community. Dengue fever is a disease caused by a family of viruses transmitted by infected mosquitoes. Author summary dengue fever, an aedes mosquitoborne viral infection, is a selflimiting or asymptomatic viral infection. The acute phase of the illness with fever and muscle pain lasts about one to two weeks. Clinical features, complications and atypical manifestations. Guidelines for treatment of dengue feverdengue hemorrhagic fever in small hospitals. Some patients with dengue fever go on to develop dengue hemorrhagic fever dhf, a severe and sometimes fatal form of the disease. Clinical profile and outcome of dengue fever and dengue. Researchers estimate 390 million infections yearly, of which 96 million have some level of severity. They may be asymptomatic or may give rise to undifferentiated fever, dengue fever, dengue haemorrhagic fever dhf, or dengue shock syndrome. Dengue viral infections are one of the most important mosquito borne diseases in the world.
Dengue is a mosquitoborne, acute febrile illness that is an important public health problem in tropical countries. The infection can result in acute febrile illness with hemorrhagic problem. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Jan 01, 2010 dengue is a major public health problem worldwide, caused by 4 dengue virus serotypes denv14 of the flavivirus genus. Dengue fever causes high fever, rash, and muscle and joint pain, bleeding, and hypotension related journals of dengue fever. Dengue is an important tropical arbovirus infection. Female mosquitoes, predominantly of the species aedesaegyptiand less commonly, aedesalbopictus,are responsible for the transmission of the dengue virus. Dengue fever virus denv is an rna virus of the family flaviviridae.
Dengue haemorrhagic fever 12 chapter 2 clinical diagnosis dengue virus infections may be asymptomatic or may lead to undifferentiated fever, dengue fever df or dengue haemorrhagic fever dhf with plasma. The association between obesity and dengue severity among. Article pdf available in iranian journal of pediatrics 183 november. This study attempts to investigate whether gallbladder wall thickening gbwt measured by ultrasonography can be used in children as a reliable criterion to predict the onset of severe dengue hemorrh. Dengue, hemorrhagic fever search for similar articles. Dengue continues to cause considerable concern in the country because of its widespread endemicity, the minimal success of. To assess the clinical profile of the dengue infection in children less than 14 years of age and to evaluate the outcomes of dengue fever from september 20 to august 2015 at the. In its severe form, severe dengue, the symptoms include organ failure, lifethreatening bleeding, and shock. Dengue infections may be asymptomatic or can result in a wide spectrum of disease severity ranging from an influenzalike illness dengue fever to the lifethreatening dengue hemorrhagic fever dhf dengue shock syndrome dss. Dengue fever is a mosquitoborne disease spread by aedes aegypti mosquito. Clinical profile and outcome in children of dengue hemorrhagic fever in north india. The presence of fever, itchy rash, and headache the dengue triad is characteristic of dengue. Dengue haemorrhagic fever has caused many a young life to be lost in the country in the recent past.261 507 1452 1337 777 494 1518 100 773 858 1369 1059 1098 1093 281 1273 1458 1497 101 1129 59 309 768 373 101 918 1236 345 327